One thing that's taken some getting used to is the use of white for highlighted text on sites with dark backgrounds; I don't really mind at all, but it was a bit of a shock at first. I like the improved extension update system and the built-in tab rearranging; no more need to use MiniIT. One or two of my extensions weren't ready for 1.5, but a day later, when I happened to check, both had already been updated. Their themes/extensions site was moving like molasses on the day of the release; I'm guessing they had to shift a lot of bandwidth toward covering the downloading.
I have 38 extensions installed, so I will wait a couple of months before upgrading. I absolutely despise it when I update, and it takes weeks for my extensions to become compatible again. "easyGestures" is the best, and without it, I can't surf!